METHOD FOR PRODUCING A solid pharmaceutical composition of valsartan and hydrochlorothiazide

摘要

A method of making a solid pharmaceutical composition of valsartan and hydrochlorothiazide, wherein the weighted valsartan, hydrochlorothiazide, part of silicon dioxide colloidal and microcrystalline cellulose is stirred in the mixer, then the resulting mixture was granulated, dusted and tableted otlichayuschiysyatem that the mixture of valsartan, hydrochlorothiazide, part of the silica colloid and cellulose microcrystalline granulated with aqueous povidone, wherein the amount of microcrystalline cellulose in the granulate is introduced, with stavlyaet 0-50% by weight of the tablet core, and the amount of microcrystalline cellulose was introduced into the mixture in unchanged form, it is 10-20% by weight of the tablet core.