NOTUM PECTINACETHYLESTERASE INHIBITORS AND WAYS OF THEIR APPLICATION

摘要

1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: X is OR or N (R); each R is independently hydrogen or an optionally substituted alkyl, aryl, heteroalkyl or heterocycle; R is hydrogen, halogen, —COR, —C ( O) N (R), —SR, —OR, —N (R) or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; each R independently represents hydrogen or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; R represents hydrogen, halogen , cyano, —COR, —C (O) N (R), —SR, —OR, —N (R), or optionally substituted al il, aryl, heteroalkyl or heterocycle; each R independently represents hydrogen or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; R represents hydrogen, halogen, —COR, —C (O) N (R), —SR, —OR, - N (R) or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; each R independently is hydrogen or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; and n is 1 or 2; where “optionally substituted” means optionally substituted with one or more of alkoxy, alkyl, amino (including alkylamino, dialkylamino), aryl, carboxylic acid, cyano, halogen, haloalkyl, heterocycle or hydroxyl. 2. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: X is OR or N (R); each R is independently hydrogen or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; R is hydrogen, halogen, —COR, —C (O) N (R), -SR, -OR, -N (R) or optionally substituted alkyl, aryl, heteroalkyl or heterocycle; each R is independently hydrogen or optionally substituted alkyl, aryl, heteroalkyl or get�