PROTEIN BIOMARKERS FOR DIAGNOSING SOFT TISSUE DISEASES AND AS THERAPEUTIC TARGETS FOR ORAL HYGIENE INTERVENTION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to pharmaceutics and represents a method for identifying a compound applicable for treating periodontal diseases, involving: preparing the first gingival sample from a mammal suffering from an oral disease or condition; preparing the second gingival sample from the mammalian oral cavity; conducting a reaction of the first sample and the analysed compound; conducting a reaction of the second sample and a positive reference that is a compound known as inhibiting an expression of one or more biomarkers specified in a group consisting of DEFB4, CTSS, BGN, BF and IL-12A (halogenated diphenyl ester); measuring a degree of inhibiting the expression of one or more biomarkers by the analysed compound; measuring a degree of inhibiting the expression of one or more biomarkers by the positive reference; and comparing the degree of inhibiting the expression of one or more biomarkers by the analysed compound to the degree of inhibiting the expression of one or more biomarkers by the positive reference; wherein the analysed compound which inhibits the expression of one or more biomarkers equally or more than the above positive reference, is a compound applicable for treating periodontitis.;EFFECT: developing the method for identifying the compound applicable for treating a periodontal disease.;4 cl, 4 ex, 2 tbl, 1 dwg