Dysfunction of axonal transport in normal-tension glaucoma:a biomarker of disease progression and a potential therapeutic target

摘要

Glaucoma and dysfunction of axonal transport:One of the leading causes of irreversible blindness worldwide is glaucoma,with increased intraocula r pressu re(IOP)being the most common risk factor.However,in some glaucoma patients it has been shown that the IOP does not differ from that of the normal population.In Japan,normal-tension glaucoma(NTG),which accounts for 92%of primary open-angle glaucoma,has been shown to be more frequent in the population.