Transdermal therapeutic systems with improved stability and methods for their production

摘要

This invention provides for, inter alia, a transdermal therapeutic system comprising at least one therapeutically active substance, which is oxidizable by hydroperoxides, wherein the amount of oxidative degradation of said active substances(s) and the corresponding formation of oxidative degradation products is reduced, which comprises one or more constituents of said transdermal therapeutic system being in contact with said active substance(s), wherein the sum of the peroxide number(s) (PON) of each of said constituents related to their percentage of the whole amount of said constituents as expressed by the formulawhereN is the percentage content of the whole amount of said constituents in the TTS,n is the number of said constituents in the TTS,i is the running numberPON is the peroxide number of each of the constituents,is not greater than 20.