首页> 外国专利> Elimination of cancer cells by Cytotoxic T cells specific for viruses using Multifunction circulating Proteins that comprise Class I MHC with Diana in cancer cells

Elimination of cancer cells by Cytotoxic T cells specific for viruses using Multifunction circulating Proteins that comprise Class I MHC with Diana in cancer cells

机译:使用多功能循环蛋白(包括I类MHC和戴安娜王妃)在癌细胞中用病毒特异的细胞毒性T细胞消除癌细胞

摘要

Herein is reported a multifunction Protein, characterized in that it comprises a domain host exactly exactly a FC region of antigen, Antibody and at least one Antigen binding site, which includes the domain host antigen, direc This n-terminal to c-terminal, B2 Microglobulin (i) and (ii) The extracellular Domains A1A2 and A3 a CHM Class I Molecule with a relative frequency of less than 1%, or (i) a Peptide Inducer T cell response, (ii) a B2 microglobulin, and (iii) The extracellular Domains A1, A2 and A3 a CHM Class I Molecule with a relative Frequency 1% or more, and N the Antigen Binding Site binds to a surface antigen of a cancer cell.Claim 13: pharmaceutical formulation comprising multifunctional Protein according to any of claims 1 to 12, and optionally a pharmaceutically acceptable Carrier.
机译:本文报道了一种多功能蛋白,其特征在于它包括恰好是抗原的FC区域的域宿主抗体,抗体和至少一个抗原结合位点,其包括域宿主抗原direc,该n端至c端B2。微球蛋白(i)和(ii)细胞外域A1A2和A3是相对频率小于1%的CHM I类分子,或(i)肽诱导剂T细胞反应,(ii)B2微球蛋白,和(iii胞外域A1,A2和A3是CHM I类分子,相对频率为1%或更高,N是抗原结合位点与癌细胞表面抗原的结合。权利要求13:包含根据任何一项所述的多功能蛋白的药物制剂13.根据权利要求1至12所述的载体,和任选地药学上可接受的载体。

著录项

  • 公开/公告号AR093641A1

    专利类型

  • 公开/公告日2015-06-17

    原文格式PDF

  • 申请/专利权人 ROCHE GLYCART AG;

    申请/专利号AR2013P104385

  • 发明设计人

    申请日2013-11-28

  • 分类号C07K16/28;A61K47;A61P35;C07K14/045;C07K14/74;C07K16/30;C07K16/46;

  • 国家 AR

  • 入库时间 2022-08-21 15:16:28

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