CD4+ T Cells Cooperate with Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells

摘要

Our present knowledge of how T cells eliminate cancer is mainly based on memory immune responses investigated with vaccinated mice. In-vivo depletion studies with anti-CD4 monoclonal antibodies (mAb) have revealed that the antitumor immunity conferred by prophylactic vaccination is usually CD4~+ T cell dependent. CD4~+ T cells were required for vaccination-induced immunity against the B16 melanoma, against the Mc51.9 fibrosarcoma, against the J558 plasmacytoma, and against the A20 lymphoma.