Removal of cancer cells by circulating virus-specific cytotoxic T cells using MHC class I targeting cancer cells containing multifunctional proteins

摘要

As used herein, a multifunctional protein comprising exactly one antigen-presenting domain, exactly one antibody Fc region, and at least one antigen-binding site, wherein the antigen-presenting domain is N to C Α1, α2 and α3 of the extracellular domain of a class I MHC molecule with (i) β2-microglobulin and (ii) a relative frequency of less than 1% in the terminal direction, or (i) a T cell response inducing peptide , (Ii) β2-microglobulin, and (iii) α1, α2, and α3 of the extracellular domain of a class I MHC molecule having a relative frequency of 1% or more, wherein the antigen binding site is a cancer cell surface antigen Multifunctional proteins that bind to are reported. [Selection] Figure 1