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REMOVAL OF CANCER CELLS BY CIRCULATING VIRUS-SPECIFIC CYTOTOXIC T-CELLS USING CANCER CELL TARGETED MHC CLASS I COMPRISING MULTI-FUNCTION PROTEINS.
REMOVAL OF CANCER CELLS BY CIRCULATING VIRUS-SPECIFIC CYTOTOXIC T-CELLS USING CANCER CELL TARGETED MHC CLASS I COMPRISING MULTI-FUNCTION PROTEINS.
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机译:通过使用包含多功能蛋白的I类MHC癌细胞靶向循环病毒特定的细胞毒性T细胞来去除癌细胞。
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摘要
Herein is reported a multi-function protein, characterized in that it comprises exactly one antigen presenting domain, exactly one antibody Fc-region, and at least one antigen binding site, wherein the antigen presenting domain comprises in N- to C-terminal direction either (i) a ß2-microglobulin, and (ii) the extracellular domains a1, a2, and a3 of a class I MHC molecule with a relative frequency of less than 1 %, or (i) a T-cell response eliciting peptide, (ii) a ß2-microglobulin, and (iii) the extracellular domains a1, a2, and a3 of a class I MHC molecule with a relative frequency of 1 % or more, wherein the antigen binding site binds to a cancer cell surface antigen.
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