An hbridio compound containing an antibiotic and a stereoscopic part, used to make an apparent pharmaceutical composition and composition

摘要

A hybrid compound comprising an antibiotic portion and a steroid portion, or a pharmaceutical salt thereof, which are connected to each other via two separate covalent bonds such that said covalent bonds are degraded in vivo to produce the respective antibiotic and steroid independently. Use of the hybrid compound, wherein the bond is an ester bond or an amide bond, to prepare a pharmaceutical composition for administration to an eye of a mammal with a bacterial infection or inflammation that affects said eye. The bacterial infection is selected from: conjunctivitis, keratitis, blepharitis, endophthalmitis, dacryocystitis, hordeolus,corneal ulcers, anterior blepharitis, posterior blepharitis, dysfunction of the meibomian gland, dry eye disease, keratoconjunctivitis sicca) eye pain and inflammation after ocular surgery, bacterial conjunctivitis, anterior uveitis, post-surgical inflammation, inflammatory conditions of palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, such as allergic conjunctivitis, ocular rosacea, dry eye, blepharitis, endophthalmitis, meibomian gland dysfunction, superficial punctate keratitis herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, chemical radiation corneal damage, or thermal burn,Appearance penetration and allergy. The drug ingredient includes a fig compound, in which the link is an ester link or an Amida link, and the drug ingredient is prepared for local ophthalmic management. 1. Characteristic 1: a fig compound, which is characterized by containing part of antibiotics and part of taxonomic sterols, or one of the pharmaceutical salts, Two different covalent links are linked together to degrade them in the field, producing antibiotics and steroids respectively.