Process for preparing Rivaroxaban and key intermediates thereof

摘要

ufeffu0159eu0161enu00ed concerns the method for preparing the rivaroxaban formula involving the reaction of (s) - 1 - chlorine - 3 - [(4-chlorophenyl) methylene) amino] propan-2-ol with benzyl 4 - (3 - oxomorfolin - 4 - yl) fenylkarbamu00e1tem and subsequent reaction product with acid methansulfonovou salt and salt 4 - {4 - [(5s) - 5 - (aminomethy (l) - 2 - oxo - 13 - oxazolidin - 3 - yl] phenyl] morpholine - 3 - the acid methansulfonovou reacts with 5 - chlorthiofen - 2 - karbonylchloridem in a mixture of solvents and in the presence of base to rivaroxaban.