Spherical smart nanotherapeutic with broad-spectrum antibacterial activity and process for preparing thereof

摘要

Hollow spherical nano particles with one macro-outer diameter between 300 and 4000 nm, the diameter of macro nanoparticles between 150 to 2000 nm, diffusion channels on the effective area of ​​0.4 to 9 nm.sup.2.n.každého of diffusion channels are skeleton consisting of covalently bonded polymer of three-dimensional cross-linked saccharide units constituting 1-50 isocentrických layers of polysaccharide, and the method, the degree and type of crosslinking controls the rate of biodegradation (metabolism) of nanoparticles in the organism to form the so-called. time nanozámek and the inner wall of the nanoparticle is covalently modified bactericides (biocides) or generally substances with antibacterial or pathogenic bacteria-inactivating effect, is prepared by polycondensation of saccharide units with crosslinking linkers. Bactericides attaching to the inner wall skeleton nanoparticles formed antibacterial nanoterapeutikum type bacterial trap, in which the principle eliminates the possibility of bacterial resistance.