Oligonucleotides for RNA interference and their biological applications

摘要

The invention relates to compositions comprising double-stranded oligonucleotides of identical or different sequences and/or length, said oligonucleotides having sequences 3N1N2 . . . Ni-1Ni . . . Nj5 wherein3Ni . . . Nj5 is half of a double-stranded 19-28mer oligonucleotide of sequence complementary to a target nucleic acid sequence present in a living cell, and3N1 . . . Ni-15 is a 3-50mer overhang of sequence allowing oligomerization of said double-stranded oligonucleotide. Compositions of transfection comprising said oligonucleotide compositions and there used for therapeutical application.