Cell culture attenuated live orf vaccine for protection of goat/sheep against orf (contagious pustular dermatitis)

摘要

The present invention relates to the development of a live attenuated vaccine for control of Orf in sheep and goat. Orf infection is most significant in small ruminants as it causes substantial losses through high morbidity, mortality, decreased productivity and hide damage. The vaccine developed here can be used to protect both sheep and goats A from clinical disease when administered at a dose of 10 30 TCID50 per animal. The vaccine is given intra-dermally at the inner aspect of thigh region in a volume of 0.2 ml per animal. The vaccine is expected to bring down the incidence of the disease contributing eventually to the enhanced productivity of small ruminant. The vaccine developed, described and claimed in this patent, can effectively be used for control of orf, where orf infection is enzootic. The orf virus can potentially exploited to as virus vector through genetic manipulation, for developing recombinant virus vectored vaccine against important pathogens.