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BREAST CANCER PROGNOSIS, PREDICTION OF PROGESTERONE RECEPTOR SUBTYPE ANDPREDICTION OF RESPONSE TO ANTIPROGESTIN TREATMENT BASED ON GENE EXPRESSION.
BREAST CANCER PROGNOSIS, PREDICTION OF PROGESTERONE RECEPTOR SUBTYPE ANDPREDICTION OF RESPONSE TO ANTIPROGESTIN TREATMENT BASED ON GENE EXPRESSION.
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机译:基于基因表达的乳腺癌预后,预测孕酮受体亚型和预测对抗孕激素治疗的反应。
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摘要
The present invention provides gene expression profiles indicative of whether a patient afflicted with PR driven malignancies is likely to be responsive to treatment with a therapeutic compound that is an anti-progestin. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non- responders. Also, provided are methods of using gene expression profiles and assays for identifying the presence of a gene expression profile in a patient. Also, provided are gene expression signatures differentiating cells expressing a K388R progesterone receptor from a wild type progesterone receptor.
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