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Breast cancer prognosis, prediction of progesterone receptor subtype andprediction of response to antiprogestin treatment based on gene expression
Breast cancer prognosis, prediction of progesterone receptor subtype andprediction of response to antiprogestin treatment based on gene expression
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机译:基于基因表达的乳腺癌预后,孕激素受体亚型预测和抗孕激素治疗反应预测
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摘要
The present invention provides gene expression profiles indicative of whether a patient afflicted with PR driven malignancies is likely to be responsive to treatment with a therapeutic compound that is an anti-progestin. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non- responders. Also, provided are methods of using gene expression profiles and assays for identifying the presence of a gene expression profile in a patient. Also, provided are gene expression signatures differentiating cells expressing a K388R progesterone receptor from a wild type progesterone receptor.
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