Linker A-18

摘要

The characteristic is that IL-18 involves both inherent immunity and obtaining immunity. The biological activity of IL-18 is negatively regulated by IL-18 binding protein (il18bp).A natural, very special inhibitor This soluble protein is formed by a free type i-18 compound, which prevents it from contacting with the type i-18 receptor, thus inhibiting and inhibiting its biological activities. The invention shows the linking molecules, including antibodies or fragments thereof, which are connected with IL-18, are not connected with IL-18, and are connected with IL-18BP (IL-18 / IL-18BP). In addition to physiological functionsThe i-18 has been shown to be an intermediate in a variety of autoimmune and flammable diseases. The chain molecule of the invention can be used as a therapeutic molecule for the treatment of autoimmunity and inflammation related to IL-18, or as a diagnostic tool for identifying, detecting and / or measuring IL-18 not connected with IL-18BP, as a component of the total reserve of IL-18.