Linker A-18

摘要

Therefore, in one aspect, the present invention provides a linker specifically connected to IL-18, wherein the linker is not connected to IL-18 / protein binding complex to IL-18 (IL-18BP),There, the linker is not IL-18BP. In one way, the link molecule is linked to the entry of IL-18 about IL-18, which is defined as SEQ ID No.1, where the entry includes arg140 and glu152 amino acids. In another way in this respect, the title may also include one or more amino acids of gln92, pro93, gly95, pro143, glu157 or glu177. In another case, the title may also include any or more amino acids of lys89, 65 10 15 20 25 arg94, met96, ph138, ser141, gly144, his145, asp146, gln150 or le180. In another caseWhen IL-18BP is connected to IL-18, the linker does not compete with IL-18BP.