Fused thiophene derivatives as kinase inhibitors

摘要

A compound of formula (IIA), or a pharmaceutically acceptable salt or solvate thereof: ** Formula ** in which -X1- represents a group of formula (a), (b) or (c): ** Formula * * Y represents oxygen or sulfur; R5 represents hydrogen, halogen, cyano, -SRa, -CORe, -CO2Rb or -CONRcRd; or R5 represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkenylcarbonyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl, C3-7 cycloalkyl (C2-6 alkenyl). ), C3-7cycloalkyl-C2-6alkynyl, aryl, aryl-C1-6alkyl, aryl-C2-6alkenyl, aryl-C2-6alkynyl, biaryl, C3-7-heterocycloalkyl, C3-15 heterocycloalkyl 7-C1-C6alkyl, C3-7 heterocycloalkyl-C2-6alkenyl, C3-7-heterocycloalkyl-C2-6alkynyl, C3-7-heterocycloalkylcarbonyl (C2-6alkynyl), heterobicycloalkyl C5-9-C2-6alkynyl, C3-7-heterocycloalkyl-aryl, C3-7-heterocycloalkyl-C1-6alkyl-aryl, heterocyclicalkyl-C3-7-biaryl, heteroaryl, heteroaryl-C1-6alkyl, heteroaryl-C1-6-alkylcarbonyl, heteroaryl-C2-6-alkenyl, heteroaryl-C2-6-alkynyl, heteroaroylcarbonyl, heterocycloalkyl-C3-7-heteroaryl, heterocycloalkyl-C3-7 -alkynyl (C2-6), heteroaryl aryl, heteroaryl-aryl-C1-6alkyl, aryl-heteroaryl, aryl-heteroaryl-C1-6alkyl, heterocycloalkyl C3-7-aryl-heteroaryl, C3-7-heterocycloalkyl (C1-6) -alkyl-heteroaryl, heterobicycloalkyl-C5-9-C1-6-alkyl-heteroaryl-arylheteroaryl, bi (heteroaryl), heterocycloalkylcarbonyl C3-7-bi (heteroaryl), aryloxyaryl, aryl-C1-6 alkoxyaryl, heteroaryl-C1-6 alkoxyaryl, aryl-C1-6-alkylaminoaryl, heteroaryl-C1-6-alkylaminoaryl, C3- cycloalkylcarbonylaminoaryl 7 arilcarbonilaminoarilo, alquilcarbonilaminoarilo aryl (C1-6) alkyl, C3-7 heterocicloalquilcarbonilaminoarilo, heteroarilcarbonilaminoarilo, aryl heterocicloalquilcarbonilaminoarilo (C3- 7), arilsulfonilaminoarilo, aryl (1-6C) -sulfonilaminoarilo, alquilsulfonilaminoarilo heteroaryl (C1-6) , C3-7 cicloalquilaminocarbonilaminoarilo, arilaminocarbonilaminoarilo, heterocicloalquilaminocarbonilaminoarilo C3- 7 heterocicloalquilaminocarbonilaminoarilo C3-7 heteroaryl-alquilaminocarbonilaminoarilo (1-6C) heterocicloalquilcarbonilcarbonilaminoarilo C3-7, C3-7 heterocycloalkyl-alquilaminocarbonilcar Barylaminoaryl (C1-6), arylcarbonylaryl, heterocycloalkylcarbonylaryl C3-7, heterocycloalkylcarbonylC3-7-alkylaryl (C1-6), arylakylaminocarbonylaryl (C1-6), heterocycloalkyl-alkylaminocarbonylarylarylarylarylarylarylarylarylarylarylaminocarbonylaryl (C1-6), C3-7-heterocycloalkylaminocarbonyl (C1-6) alkylaryl, C3-7-heterocycloalkyl-C1-C6-alkylaminocarbonyl-C1-6-alkylaryl, (C1-6) heteroarylaminocarbonyl-alkylaminocarbonyl (C1-6) 6) -C1-6alkylaryl, arylaminoheteroaryl, heterocycloalkylaminomino C3-7-aryl-heteroaryl, heterocycloalkylcarbonylamino C3-7-aryl-heteroaryl, heterocycloalkylaminocarbonylamino C3-7-aryl-heteroaryl, heterocycloalkylcarbonyl-C3-aryl-heteroaryl -7-C 1-6 -alkylcarbonyl -aryl-heteroaryl, heterobicycloalkylcarbonyl C5-9-arylheteroaryl, heterocycloalkylcarbonyl C3-7-alkyla (C1-6) -aryl-heteroaryl, heterocycloalkylaminocarbonyl C3-7-aryl-heteroaryl, heterocycloalk C3-7-uyl-C1-C6-alkylaminocarbonyl-aryl-heteroaryl or C3-7-C1-C6-alkylaminocarbonyl-heteroaryl-heteroaryl, any of whose groups may be optionally substituted with one or more substituents independently selected from halogen, cyano, nitro, oxo, C1-6alkyl, trifluoromethyl, hydroxy, hydroxy (C1-6alkyl), C1-6alkoxy, dihydroxy-C1-6alkoxy, aryl-C1-6alkoxy, methoxyaryl-alkoxy ( C1-6), amino, C1-6 alkylamino, dialkyl amino (C1-6), amino (C1-6) alkyl, C1-6 alkylamino-C1-6 alkyl, di-C1-6 alkylamino-C1-alkyl -6), (C1-6) dialkylamino-(C1-6) alkylamino, methoxyaryl-C1-6-alkylamino, C1-6-alkylcarbonylamino, C1-6-alkoxycarbonyl (C1-6) -alkylcarbonylamino-C1-6-alkyl (C1-6), C1-6 alkoxycarbonylamino, N- (C1-6 alkoxycarbonyl) -N- (C1-6 alkyl) amino, C1-6 alkoxycarbonylamino (C1-6) alkyl, N- (C1-6 alkoxycarbonyl) -N- (C1-6alkyl) amino-C1-6alkyl, C1-6alkylsulfonylamino, C1-6alkylsulfonylamino (C1-alkyl) 6), C1-6 alkylaminocarbonylamino, (C1-6) dialkylamino-(C1-6) alkylaminocarbonylamino, N- (C1-6alkyl) -N- [dialkyl (C1-6) -alkyl (C1-6) alkyl] aminocarbonylamino, carboxycarbonylamino, C1-6 alkoxycarbonylcarbonylamino, C1-6 alkylaminocarbonylcarbonylamino, (C1-6) dialkylamino-(C1-6) alkylaminocarbonylcarbonylamino, (C1-6) dialkylamino sulfonylamino, (C1-6) dialkylamino (C1-6) -alkylcarbonyl -6), carboxy, carboxy-C1-6alkyl, C1-6alkoxycarbonyl, C1-6alkoxycarbonyl-C1-6alkyl, aminocarbonyl, C1-6alkylaminocarbonyl, (C1-6) dialkylaminocarbonyl (C1- 6), di-C1-6 alkylamino-C1-6 alkylaminocarbonyl, dihydroxy-C1-6alkylaminocarbonyl, N- (C1-6alkyl) -N- [amino (C1-6) alkyl] aminocarbonyl, N - (C1-6 alkyl) -N