Human monoclonal antibody against alpha toxin derived from S. aureus and its use in the treatment or prevention of abscess formation

摘要

Monoclonal antibody specific for S. aureus alpha toxin, in which the variable region of the antibody light chain comprises SEQ ID NO: 1 in the CDR1 region, SEQ ID NO: 2 in the CDR2 region and SEQ ID NO: 3 in the CDR3 region, and in which the variable region of the antibody heavy chain comprises SEQ ID NO: 4 in the CDR1 region, SEQ ID NO: 5 in the CDR2 region and SEQ ID NO: 6 in the CDR3 region, or a fragment thereof that can bind to S. aureus alpha toxin, in which the fragment is a Fab or F (ab ') 2 fragment or a mixture thereof.