A monoclonal antibody or fragment thereof capable of binding the HCV E2 glycoprotein of genotypes 1a, 1b, 2a, 2b, 3, 4, 5 and 6 of HCV, wherein the monoclonal antibody or fragment thereof comprises at least one region heavy chain variable comprising the amino acid sequence SEQ ID NO: 1 or a sequence at least 95% identical to SEQ ID NO: 1 and at least one light chain variable region comprising the amino acid sequence SEQ ID NO: 2 or a sequence at least 95% identical to SEQ ID NO: 2, for use in the therapeutic treatment or prevention of HCV infections.
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机译:能够结合HCV基因型1a,1b,2a,2b,3、4、5和6的HCV E2糖蛋白的单克隆抗体或其片段,其中该单克隆抗体或其片段包含至少一个区域重链变量,该区域包含氨基酸序列SEQ ID NO:1或与SEQ ID NO:1至少具有95%同一性的序列,以及至少一个包含氨基酸序列SEQ ID NO:2或与SEQ至少具有95%同一性的序列的轻链可变区编号:2,用于治疗或预防HCV感染。
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