The present invention relates to homodimeric tetravalent antigen-binding polypeptides, either monospecific or bispecific, polynucleotides encoding said binding polypeptides, expression vectors comprising these polynucleotides and prokaryotic or eukaryotic host cells comprising these polynucleotides or vectors. Furthermore, the invention relates to therapeutic and diagnostic uses of said structures in the fields of oncology, inflammatory and immune disorders.
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