MICRO- AND NANOSTRUCTURED PHARMACEUTICAL AND VETERINARY COMPOSITIONS, CONTAINING BENZNIDAZOLE AND DERIVATIVES THEREOF, WHICH FORM MICRO- AND NANOSTRUCTURES IN THE GASTROINTESTINAL TRACT, AND BIOLOGICAL USES THEREOF

摘要

The present invention describes methods for preparing micro- and nano-scale polymeric pharmaceutical forms encapsulating benznidazole for parenteral administration, and pharmaceutical forms for oral administration, which self-emulsify in contact with biological fluids, forming micro- or nanoemulsions. Microcapsules, microspheres, microemulsions, nanocapsules, nanospheres, nanoemulsions, solid, semi-solid and liquid lipid nanoparticles, lipid-core nanocapsules and self-emulsifying systems, which form micro- and nanoemulsions, are included. The formulations sought to be patented include pharmaceutical forms having a structure of emulsified globules, optionally coated with polymers, containing a benznidazole and/or nitroimidazole derivative. The pharmaceutical compositions developed improve the dissolution profile of benznidazole, control drug release and increase plasmatic bioavailability, with a consequent improvement in pharmacological activity.