pharmaceutical and veterinary compositions in micro and nanostructured forms and forming micro and nanostructures in the gastrointestinal tract containing benznidazole and its derivatives and their biological applications

摘要

Pharmaceutical and veterinary compositions in micro and nanostructured forms and forming micro and nanostructures in the gastrointestinal tract containing benznidazole and its derivatives and their biological applications The present invention describes the methods of preparing micro and nanometric polymeric dosage forms by encapsulating benznidazole for parenteral and parenteral use. oral dosage forms that self-emulsify in contact with biological fluids, forming micro or nanoemulsions. include microcapsules, microspheres, microemulsions, nanocapsules, nanospheres, nanoemulsions, solid, semi-solid and liquid lipid nanoparticles, lipid core nanocapsules and self-emulsifying systems that form micro and nanoemulsions. Formulations to be patented include pharmaceutical forms having emulsified cell structure coated or not with benznidazole-containing polymers and / or one of nitroimidazole derivatives. The developed pharmaceutical compositions improve the dissolution profile of benznidazole, control drug release and promote increased plasma bioavailability, with consequent improvement in pharmacological activity.