A pharmaceutical compositon containing SkullcapflavoneⅡ or pharmaceutically acceptable salt thereof for the prevention or treatment of asthma

摘要

The present invention is effective acceptable salt or a pharmaceutically Skull Cop isoflavones It relates to a pharmaceutical composition for the prevention or treatment of asthma containing a component, specifically a skull Cobb flavone compound which inhibits weight loss caused by asthma, and can alleviate the airway hypersensitivity, serum, BAL liquid within the IgE, ovalbumin-specific IgE, interleukin-4, 5, 13, and MMP-9 production of collagen erosion around the trachea, it is possible to inhibit bronchial inflammatory cell infiltration and mucus secretion in the bronchial only have low liver toxicity as well, and further, reduce the concentration of TGF-1, Smad7 is expressed to be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of bronchial asthma by inhibiting the growth and pSmad2 / 3 levels. ;