首页> 外国专利> NOVEL 4-SUBSTITUTED OXAZOLOQUINOLINONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF ALLERGIC DISEASES INCLUDING ASTHMA OR ATOPIC DERMATITIS COMPRISING SAME

NOVEL 4-SUBSTITUTED OXAZOLOQUINOLINONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF ALLERGIC DISEASES INCLUDING ASTHMA OR ATOPIC DERMATITIS COMPRISING SAME

机译:新型4取代的恶唑烷喹啉酮衍生物,其药学上可接受的盐以及预防或治疗过敏性疾病的药物组合物,包括哮喘或原子性皮肤病

摘要

The present invention relates to a 4-substituted oxazoloquinolinone derivative, and a compound, which is a salt of the derivative, that show effects of preventing and treating allergic diseases, such as asthma or atopic dermatitis, by controlling intracellular signal transduction due to IL-33. The derivative and the compound of the present invention can effectively suppress the formation of inflammatory reactions of allergic diseases, such as asthma or atopic dermatitis, and thus, a pharmaceutical composition comprising the derivative and the compound can be used to fundamentally prevent or treat various allergies and asthmatic diseases.
机译:本发明涉及一种4-取代的恶唑并喹啉酮衍生物,以及作为该衍生物的盐的化合物,其通过控制由于IL-引起的细胞内信号转导而显示出预防和治疗变应性疾病例如哮喘或特应性皮炎的作用。 33。本发明的衍生物和化合物可有效抑制哮喘或特应性皮炎等过敏性疾病的炎症反应的形成,因此,包含该衍生物和化合物的药物组合物可用于从根本上预防或治疗各种变态反应。和哮喘病。

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