Composition for prevention or treatment of bone disease containing skullcapflavone derivatives or pharmaceutically acceptable salts thereof as an active ingredient

摘要

The present invention relates to a pharmaceutical composition for preventing or treating bone diseases, comprising skullcapflavone derivatives or pharmaceutically acceptable salts thereof as an active ingredient. According to the present invention, it was confirmed that when BMM cells are treated with RANKL in the presence of the skullcapflavone derivatives, the differentiation of osteoclasts is significantly suppressed, and the expressions of the following members are suppressed: NFATc1 related to the differentiation of osteoclasts and target genes thereof; c-Fos which is known to be an upstream regulator of NFATc1; MAPKs and Src-AKT which are activated by RANKL; CREB-PGC-1 which is involved in mitochondrial biogenesis and target genes thereof; and caveolin-1 which promotes the differentiation of osteoclasts. Additionally, as the expressions of a redox-sensitive transcriptional factor, Nrf2 and target protein thereof which is an antioxidant enzyme, and FOXO1 and catalase are increased, the production of active oxygen species is decreased, bone resorption function of osteoclasts is reduced, and inflammation-induced bone damage is suppressed. Accordingly, the skullcapflavone derivatives of the present invention can be beneficially used in preventing or treating bone diseases.