A method for the mass production of succinic acid by use of Actinobacillus succinogenes through the application of cell-recycled continuous fermentation process

摘要

The present invention relates to a continuous fermentation process for bacterial recirculation using Actinobacillus succinogenes, wherein the yield of succinic acid is about 60 g / L when the cells are recycled, and the productivity is 3.873 g / L per hour Succinic acid production. In the recycling fermentation process of the cells, the cell mass was more than 2 times higher than that of the normal continuous culture, and the succinic acid production was 5 times higher and the productivity of succinic acid was increased more than 8 times. This high productivity and high yield of succinic acid production process can reduce the production cost compared to the conventional batch culture, and it enables the production to be carried out at the level of industrialization even on the pilot scale without making large scale culture units. Therefore, when the process of the present invention is introduced, industrial application is expected to be more advantageous.