1,4-OXAZEPINES AS BACE1 AND (OR) BACE2 INHIBITORS

摘要

1. A compound of formula I where R is selected from the group consisting of i) hydrogen, ii) halogen and iii) C-alkyl; R is selected from the group comprising i) hydrogen, ii) C-alkyl and iii) halogen-C-alkyl; R is selected from the group consisting of i) halogen , ii) hydrogen and iii) C-alkyl; R is selected from the group consisting of i) hydrogen and ii) halogen; R is selected from the group comprising i) hydrogen and ii) C-alkyl; R is selected from the group comprising i) hydrogen and ii) C-alkyl; R is selected from the group including i) halogen and ii) C-alkyl; n is 0 or 1; R is selected from the group consisting of i) heteroaryl, ii) heteroaryl containing 1-4 substituents, is individually selected s from the group consisting of cyano, cyano-C-alkyl, halogen, halogen-C-alkyl, halogen-C-alkoxy, C-alkoxy and C-alkyl; iii) heteroaryl-CH-, iv) heteroaryl-CH- containing 1-4 substituents individually selected from the group consisting of cyano, cyano-C-alkyl, halogen, halogen-C-alkyl, halogen-C-alkoxy, C-alkoxy and C-alkyl; v) aryl, vi) aryl containing 1-4 substituents individually selected from the group consisting of cyano, cyano-C-alkyl, halogen, halogen-C-alkyl, halogen-C-alkoxy, C-alkoxy and C-alkyl, vii) heterocyclyl and viiii) goethe rocyclyl containing 1-4 substituents individually selected from the group consisting of cyano, cyano-C-alkyl, halogen, halo-C-alkyl, halogen-C-alkoxy, C-alkoxy and C-alkyl; or pharmaceutically acceptable salts thereof. 2. The compound of formula Ia according to claim 1, where R is selected from the group consisting of i) hydrogen, ii) halogen and iii) C-alkyl; R is selected from the group including i) hydrogen, ii) C-alkyl and iii) halogen-C-alkyl; R is selected from the group consisting of i ) halogen, ii) hydrogen and iii) C-alkyl; R is selected from the group consisting of i) hydrogen and ii) halogen; R is selected from the group comprising i) hydrogen and ii