DEVICE FOR DIRECTION OF CELL MIGRATION AND METHOD OF DIRECTION OF CELL MIGRATION BY SUCH DEVICE

摘要

1. A device for directing cell migration, containing a substrate with a textured surface intended for contact with cells and having an anisotropic three-dimensional structure consisting of a network of protrusions inclined relative to the normal to the plane formed by said textured surface in the direction specified by the anisotropic structure. . The device according to claim 1, characterized in that the network of protrusions has gaps smaller than the size of the cells, preferably less than 20 microns, more preferably 0.1 to 15 microns, even more preferably 5 to 10 microns, and most preferably approximately 5 μm. 3. The device according to claim 1, characterized in that the inclined protrusions have an angle of inclination relative to the normal to the plane formed by said textured surface, less than or equal to 45 °, and preferably from 10 ° to 45 °. 4. The device according to claim 1, characterized in that the ratio of the height of the inclined protrusions to their diameter is from 0.5 to 20, preferably from 2 to 10.5. The device according to claim 1, characterized in that the inclined protrusions are in the form of cylinders having, in particular, a round or oval cross section, cones, pyramids, plates having, in particular, a cross section in the form of a rectangle or parallelogram, or flakes, essentially triangular, semi-elliptical or semicircular. 6. The device according to claim 5, characterized in that the inclined protrusions are in the form of cylinders with a diameter of from 10 nm to 10 μm, preferably from 0.5 to 3 μm. The device according to claim 1, characterized in that the substrate with a textured surface is made adhesive. Device