According to the invention, the cells 3 are confined between the support surface 2 and the texture surface 3 of the substrate 5, and the texture surface 6 is a repeating pattern Wherein the repeating pattern has continuous guide spaces 15 adjacent to each other along the repetition axis X and each of the guide spaces 15 is formed by a plurality of cells 3, A cell migration guide device is proposed which is oriented in an anisotropic direction (A1), which can accommodate at least a part of cells in the anisotropic direction (A1) and guide the movement of the cells (3).
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