MONOCLONAL ANTIBODY ABLE TO BIND TO SPECIFIC DISCONTINUOUS EPITOPE PLACED IN AD1 REGION OF HUMAN CYTOMEGALOVIRUS GB GLYCOPROTEIN, AND ITS ANTIGEN-BINDING FRAGMENT

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to biochemistry, particularly to a monoclonal antibody or its antigen-binding fragment, which specifically binds to AD1 region of human cytomegalovirus (HCMV) gB glycoprotein, as well as to a nucleic acid coding it. What is disclosed is a pharmaceutical composition for preventing or treating a HCMV-related disease containing an effective amount of the above antibody or its antigen-binding fragment. There are also described an expression vector containing the above nucleic acid and a host cell containing the above vector. A method for producing the above antibody or antigen-binding fragment consisting of the stages 1) culturing the above host cell and 2) purifying the produced antibody from the culture supernatant.;EFFECT: invention enables treating the HCMV-related diseases effectively.;10 cl, 11 dwg, 8 tbl, 11 ex