首页> 外国专利> NUCLEOSIDE TRIPHOSPHATE DERIVATIVE, NUCLEIC ACID PROBE, MULTILABELED NUCLEIC ACID PROBE, METHOD FOR PRODUCTION OF MULTILABELED NUCLEIC ACID PROBE, AND METHOD FOR DETECTION OF TARGET NUCLEIC ACID

NUCLEOSIDE TRIPHOSPHATE DERIVATIVE, NUCLEIC ACID PROBE, MULTILABELED NUCLEIC ACID PROBE, METHOD FOR PRODUCTION OF MULTILABELED NUCLEIC ACID PROBE, AND METHOD FOR DETECTION OF TARGET NUCLEIC ACID

机译:核苷三磷酸衍生物,核酸探针,多标签核酸探针,多标签核酸探针的生产方法以及目标核酸的检测方法

摘要

A novel nucleoside triphosphate derivative, a nucleic acid probe, and a multilabeled nucleic acid probe that can detect a target nucleic acid conveniently and with high sensitivity, as well as a method for producing the multilabeled nucleic acid probe, and a method for detecting a target nucleic acid using the multilabeled nucleic acid probe or the nucleic acid probe. A target nucleic acid can be detected conveniently and with high sensitivity by using a transglutaminase (TGase), and by using a multilabeled nucleic acid probe in which a plurality of labeling portions have been introduced in advance by covalent binding, or by introducing a plurality of labeling portions by covalent binding into a nucleic acid probe that has been hybridized with the target nucleic acid.
机译:可以方便且高灵敏度地检测靶核酸的新型核苷三磷酸衍生物,核酸探针和多标记核酸探针,以及制备该多标记核酸探针的方法和靶的检测方法使用多标记核酸探针或核酸探针的核酸。通过使用转谷氨酰胺酶(TGase),并且通过使用预先通过共价结合引入了多个标记部分的多标记核酸探针,或通过引入多个标记核酸,可以方便且高灵敏度地检测靶核酸。通过共价结合到已经与靶核酸杂交的核酸探针中来标记部分。

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