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Modified glyoxylate shunt for improved production of aspartic acid-derived amino acids and chemicals
Modified glyoxylate shunt for improved production of aspartic acid-derived amino acids and chemicals
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机译:改性乙醛酸酯分流器可改善天冬氨酸衍生氨基酸和化学品的生产
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摘要
The invention provides microbial strains possessing improved properties for production of aspartate-derived amino acids and chemicals. Methods of making such strains are provided. These methods include altering expression of the aceBAK operon, the glcB gene, or both. Alteration of expression may be accomplished through increased transcription, relief from native transcriptional control, and/or other means. Replacement of native promoters for these genes is also contemplated; for instance, their native promoters may be replaced by the tac promoter (Ptac).
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