首页> 外国专利> A composition for treating, preventing or ameliorating macular degeneration comprising a blackberry extract or a blackberry fraction as an active ingredient

A composition for treating, preventing or ameliorating macular degeneration comprising a blackberry extract or a blackberry fraction as an active ingredient

机译：用于治疗，预防或改善黄斑变性的组合物，其包含黑莓提取物或黑莓级分作为活性成分。

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摘要

The present invention relates to a composition for treating, preventing or relieving macular degeneration, containing a Vaccinium uliginosum extract or Vaccinium uliginosum fractions as an active ingredient. The Vaccinium uliginosum extract and Vaccinium uliginosum fractions, which are active ingredients of the present invention, suppress the accumulation of A2E on retinal pigment epithelial cells and inhibit the oxidation of A2E to effectively protect retinal pigment epithelial cells, and thereby prevent the cause of macular degeneration. Therefore, the composition of the present invention can be developed into various products such as a pharmaceutical, a dietary supplement, and the like, for excellently treating or relieving macular degeneration.

机译：本发明涉及一种用于治疗，预防或缓解黄斑变性的组合物，其包含小叶越橘提取物或小叶越橘组分作为有效成分。作为本发明的活性成分的牛痘菌提取物和牛肝菌级分，抑制了A2E在视网膜色素上皮细胞上的积聚，并且抑制了A2E的氧化，有效地保护了视网膜色素上皮细胞，从而防止了黄斑变性的原因。。因此，本发明的组合物可以被开发成各种产品，例如药物，饮食补充剂等，以优异地治疗或缓解黄斑变性。

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公开/公告号JP5860418B2

专利类型
公开/公告日2016-02-16

原文格式PDF
申请/专利权人チョウン、ス－ヨン;
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申请/专利号JP20120556977
发明设计人チョウン、セ－ヨン;
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申请日2011-03-09
分类号A61K36/45;A61P27/02;
国家 JP
入库时间 2022-08-21 14:43:12

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7. TITLE:ACTIVE INGREDIENT COMPOSITION COMPRISING VEGETABLE EXTRACTS FOR USE IN COSMETIC PRODUCTS [J] . Soap Perfumery and Cosmetics Group Soap, Perfumery and Cosmetics . 2007,第9期

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11. 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Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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