2- (Hetero) arylbenzimidazole and imidazopyridine derivatives as inhibitors of asparagine methyltransferase

摘要

Substituted benzimidazole and 3H-imidazo [4,5-b] pyridine or Formula I: [wherein X and Y are selected from (i) N and N respectively; and (ii) N and CR 4:; A 2 is 2 Or a C5 heteroarylene group containing 3 ring heteroatoms, wherein the bond to L1 and the bond to the center are β with respect to each other; L1 is (i) A1-O-CH2- (Ii) A1-CH2-O-A2; (iii) A1-C (= O) -NH-A2; (iv) A1-CH (OH) -A2; (v) A1-CH2-NH-C (= O) -A2; (vi) A1-S-CH2-A2; (vii) A1-CH2-S-A2; (viii) A1-CH2-A2; and (ix) A1-CH (CH3) -O -A2: selected; A1 is phenyl optionally substituted with F or CF3], their use as pharmaceuticals, especially in the treatment of cancer and abnormal hemoglobinosis