It is an object of the present invention to provide a newly identified insulin secretion regulation factor that can control blood sugar in the normal range, and a method for screening an antidiabetic drug using said factor. In accordance with the present invention, there is provided a composition which is (i) a protein comprising an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4 and negatively regulating insulin secretion, as well as a method for screening antidiabetic drug using said protein or a nucleic acid encoding the same.
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机译：本发明的一个目的是提供一种新近鉴定的可以将血糖控制在正常范围内的胰岛素分泌调节因子，以及使用所述因子筛选抗糖尿病药的方法。根据本发明，提供了一种组合物，该组合物是（i）一种蛋白质，其包含由SEQ ID NO：2或SEQ ID NO：4表示的氨基酸序列; （ii）一种蛋白质，其包含在SEQ ID NO：2或SEQ ID NO：4表示的氨基酸序列中缺失，取代或添加一个或多个氨基酸的氨基酸序列，并且还负调节胰岛素分泌作为使用所述蛋白质或编码该蛋白质的核酸筛选抗糖尿病药的方法。
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