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METHOD FOR THE SOLID-PHASE BASED SYNTHESIS OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
METHOD FOR THE SOLID-PHASE BASED SYNTHESIS OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES
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机译:固相合成磷酸桥核缀合物的方法
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摘要
A method for producing phosphate-bridged nucleoside conjugates, in particular poly- or oligonucleosides. In the method, an immobilized cyclosaligenyl derivative of a nucleoside, nucleotide, poly- or oligonucleotide, poly- or oligonucleoside, or an analog thereof, is synthesized, and the subsequent reaction with a nucleophile yields the desired phosphate-bridged nucleoside conjugate, which may subsequently be released from the solid phase.
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