2-(R2-THIO)-10-3-(4-R1-PIPERAZIN-1-YL)PROPYL-10H-PHENOTHIAZINES FOR TREATING A B-AMYLOIDOPATHY OR AN A-SYNUCLEOPATHY, AND METHOD FOR THE DIAGNOSIS OR PREDIAGNOSIS THEREOF

摘要

The invention relates to 2-(R²-thio)-10-[3-(4-R¹-piperazin-1-yl)propyl]- 10H-phenothiazine according to general formula I, for treating a β-amyloidopathy or an α-synucleinopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter. The invention also relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances transported by the cerebral ABCC1 transporter.