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Functional assay for identification of loss-of-function mutations in genes
Functional assay for identification of loss-of-function mutations in genes
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机译:鉴定基因功能丧失突变的功能测定
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摘要
Provided herein are compositions and methods for assaying the deleteriousness of putative loss-of-function mutations, especially in genes known to be or suspected of being tumor-suppressor genes. The invention includes syngeneic variance libraries and methods of construction and use of syngeneic variance libraries.
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