G-RICH isoDNA SEQUENCES FORMING G-QUADRUPLEX STRUCTURE, THEIR FUNCTION AS APTAMERS AND A PROCESS FOR THE PREPARATION THEREOF

摘要

The present invention relates to a kind of methods that tetra- serobilas of ABSTRACT G-QUADRUPLEX FORMING ISODNA APTAMERS AND PROCESS FOR THE PREPARATION THEREOF G- form isoDNA aptamers and its preparation. It is non-genetic the invention further relates to a kind of stabilization, guanine 2-5 " abundant ' connection ' isoDNA be selected from 3 deoxidation, 2 isoDNA ' of '-5 and ' 2-5 ' isoDNA-isoRNA of the deoxidation of ' 3 mixing. Instantaneous 2 ' -5 ' link isoDNA such as fibrin ferment combination aptamers (isoTBA) can be used for deep vein thrombosis and be formed, and be required in long-term anticoagulating active.