amino substituted bisphenyl pentanoic acid derivatives as nep inhibitors

摘要

amino substituted bisphenyl pentanoic acid derivatives as nep inhibitors. The present invention relates to a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein r 1, 4, r 2, r 3, a 1, x, x 1, s and n are defined herein. The invention also relates to a process for preparing the compounds of the invention and their therapeutic use. The present invention further provides the pharmaceutical composition of the compounds of the invention and a combination of pharmaceutically active agents and a compound of the invention.