modified social wasp venom peptide and its use as antiepileptic and neuroprotective

摘要

Modified peptide of social wasp venom and its use as antiepileptic and neuroprotective epilepsy refers to a set of diseases characterized by the occurrence of spontaneous and recurrent epileptic seizures, caused by several causes that cause focal or widespread simultaneity of brain neuron firings (seizures). ). Despite their availability, conventional and "new generation" antiepileptic drugs are commonly associated with side effects, which may vary in frequency and severity. In addition, these drugs are ineffective in controlling epileptic seizures in about 30% of patients, reaching up to 70% in patients with temporal lobe epilepsy. In view of these limitations, the present technology proposes an antiepileptic and neuroprotective peptide, designed from a described polybia social wasp venom peptide, which has been synthesized and evaluated in experimental epilepsy models (video-eeg and behavioral). , and reducing expression of c-fos proteins. This peptide had a potent antiepileptic and neuroprotective effect, both systemically and intracerebrally.