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Peptide modified with venom of Vespa social and its use as an analgesic

机译:Vespa social毒液修饰的肽及其作为止痛药的用途

摘要

Peptide modified with venom of Vespa social and its use as an analgesic. The present invention relates to a peptide derived from the venom of Vespa neuroativo, preferably of the species parachatergus fraternus, from protonectina, which was modified to achieve a compound is more stable and more potent activity, protonectina - f.The proposal of the invention is to develop a drug able to produce analgesic response dose dependently, with results comparable to those of morphine and without the adverse effects that this compound promotes the patient during treatment of chronic pain. In this context, this peptideo has no hemolytic activity and does not induce motor clumsiness in effective doses.
机译:用Vespa social毒液修饰的肽及其作为止痛剂的用途。本发明涉及一种肽,其衍生自维斯帕神经神经毒蛇的毒液,优选地来自Protonectina的蛇毒属的一种,经修饰以实现化合物更稳定且更有效的活性,Protonectina-f。开发一种能够剂量依赖性地产生镇痛反应的药物,其结果可与吗啡相媲美,并且没有这种化合物在治疗慢性疼痛过程中对患者产生的不利影响。在这种情况下,该肽没有溶血活性,并且在有效剂量下不引起运动笨拙。

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