COMBINATION AND COMPOSITION OF A SELECTIVE AND SPECIFIC SINUS NODE ICURRENT INHIBITOR AND AN AGENT THAT INHIBITS ANGIOTENSIN-CONVERTING ENZYME, AND USE THEREOF FOR TREATING HEART FAILURE

摘要

Use of the combination and composition of a selective and specific sinus node Icurrent inhibitor ivabradine or N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxo-1-propanamine and an agent that inhibits angiotensin-converting enzyme and which is perindopril or one of its addition salts with a pharmaceutically acceptable base, or hydrates or crystalline forms thereof, in obtaining medicaments intended for the treatment of heart failure having preserved systolic function.