Effect of Angiotensin-Converting Enzyme Inhibitors, Beta- Adrenoblockers and Their Combinations on Survival and Blood Plasma Catecholamine Levels in Rats with Chronic Heart Failure with Induced Exacerbations

摘要

It has been shown, using the model of the chronic heart failure proceeded with induced decompensations, that the ACE inhibitors and β-adrenoblockers promoted at different degree the correction of hypercatecholaminemia and an increase of the rat survival. The β-adrenoblockers Atenolol, Propranolol and Carvedilol had the most effect. The remaining β-adrenoblockers, not possessing the inner sympathetic-mimetic activity, as well as Captopril, demonstrated the less activity. However the positive effect of these preparations occurred on the rat survival independent on the expression of their modulating effect on the sympathetic -adrenal system. The ACE inhibitors, especially the hydrophilic Lisinopril, prevent at less degree, than the β-adrenoblockers, the death of animals at the period of CHF exacerbation. A combine using of β-adrenoblockers with the ACE inhibitors, especially with the Carvedilol, promotes a maximally expressed decrease of the sympathetic-adrenal activity and an increase of the rat survival, especially at the period of CHF exacerbation.