(AZA) PYRIDOPYRAZOLOPIRIMIDINONES AND INDAZOLOPIRIMIDINONES AS FIBRINOLYSIS INHIBITORS

摘要

The present invention relates to new substituted (aza) pyridopyrazolopyrimidinones and indazolopyrimidinones, to methods for their preparation, to compounds for use individually or in combination in a method of treating and / or preventing diseases, in particular in a method of treating and / or preventing acute and recurrent bleeding in patients with and without hereditary or acquired baseline bleeding disorders, when the indicated bleeding is associated with a disease or medical intervention selected from the group consisting of and menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, apoplexy, liver disease, hereditary angioedema, epistaxis and synovitis, as well as damage to cartilage due to hemarthrosis.