IMPROVED HIGH CELL DENSITY FERMENTATION PROCESS FOR HIGH YIELD AND SOLUBLE EXPRESSION OF RECOMBINANT INTERFERON ALPHA 2B IN E COLI

摘要

The present invention relates to the high yielding process of recombinant expression of interferon alpha 2b in soluble form by fermentation of recombinant E coli cells in a fermentation medium at low temperature during induction phase with specific feeding rates.