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Cycloalkanopyrrolocarbazole derivatives and the usethereof as parp, vegfr2 and mlk3 inhibitors

机译：环烷吡咯并咔唑衍生物及其作为parp，vegfr2和mlk3抑制剂的用途

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摘要

The present invention is directed to novel multicyclic molecules of Formula (IIIIa)* that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP3 VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

机译：本发明涉及介导酶活性的式（IIIIa）*的新型多环分子。特别地，所述化合物可有效治疗与PARP3 VEGFR2和MLK3酶的活性有关的疾病或疾病状态，包括例如神经退行性疾病，炎症，局部缺血和癌症。

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公开/公告号IN2015KN03716A

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公开/公告日2016-03-04

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申请/专利号IN3716/KOLNP/2015
发明设计人 CHATTERJEE SANKAR;HUDKINS ROBERT L;DANDU REDDEPPAREDDY;DIEBOLD JAMES L;WELLS GREGORY J;DUNN DEREK;ZULLI ALLISON L;
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申请日2015-11-09
分类号A61P17/06;A61K31/4453;A61K31/501;C07D471/14;A61K31/4196;A61K31/41;A61P43/00;A61K31/427;A61K31/4178;C07D491/14;C07D491/04;A61P15/00;A61P9/10;C07D495/04;A61P27/02;A61P3/10;A61K31/5377;A61K31/4412;A61K31/437;A61K31/407;C07D519/00;C07D487/04;A61P35/00;A61P29/00;A61P25/28;A61P25/16;A61P25/14;A61K31/497;A61K31/4439;
国家 IN
入库时间 2022-08-21 14:24:52

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