首页> 外文OA文献 >Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

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Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

机译：抑制盛开综合征蛋白（BLM）螺旋酶，触发端粒区域触发DNA损伤的新喹唑啉酮衍生物的设计，合成和评价，并用PARP抑制剂进行促进

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1. Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors [J] . Wang Chen-Xi, Zhang Zi-Lin, Yin Qi-Kun, Journal of Medicinal Chemistry . 2020,第17期

机译：抑制盛开综合征蛋白（BLM）螺旋酶，触发端粒区域触发DNA损伤的新喹唑啉酮衍生物的设计，合成和评价，并用PARP抑制剂进行协同
2. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair [J] . Yin Qi-Kun, Wang Chen-Xi, Wang Yu-Qing, Journal of Medicinal Chemistry . 2019,第6期

机译：发现ISAINDIGOTONE衍生物作为新颖的绽放综合征蛋白（BLM）螺旋酶抑制剂，破坏BLM / DNA相互作用并调节同源重组修复
3. Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors [J] . Ramadan Sayed K., Elrazaz Eman Z., Abouzid Khaled A. M., RSC Advances . 2020,第49期

机译：作为抗肿瘤PARP-1抑制剂的新喹唑啉酮衍生物的设计，合成和硅研究
4. Evaluation of Matrix Metalloproteinase-9 (MMP-9) and its tissue inhibitor of metalloproteinase-1 (Timp-1) in patients with coronary syndromes after percutaneous intervention(PCI) [C] . Revnic F., Revnic C.R., Nica A., International Congress on Coronary Artery Disease . 2011

机译：经皮干预后冠状动脉综合征患者中基质金属蛋白酶-9（MMP-9）及其组织抑制剂及其组织抑制剂（PCI）
5. Structure-Based Drug Design in Medicinal Chemistry: I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition [D] . Lee, Minhee 2017

机译：药物化学中基于结构的药物设计：I.跨病变合成抑制剂的开发II。磺酰哌嗪衍生物对LpxH的抑制作用及其合成及生物学评价
6. Analogs of the novel phytohormone strigolactone trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair [O] . Michael P. Croglio, Jefferson M. Haake, Colin P. Ryan, 2016

机译：新型植物激素strigolactone的类似物通过诱导DNA损伤和抑制DNA修复来触发细胞凋亡并与PARP抑制剂协同作用
7. Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair [O] . Michael P. Croglio, Jefferson M. Haake, Colin P. Ryan, 2016

机译：通过诱导DNA损伤和抑制DNA修复，新型植物激素，滴虫，触发凋亡和与PARP抑制剂的协同作用

Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

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